AstraZeneca vaccination: Denmark reports two more cases of blood clots

Denmark on Saturday announced two more cases of blood clots and associated cerebral hemorrhage that occurred after being vaccinated with AstraZeneca’s Covid-19 vaccine. Two hospital employees are affected. Accordingly, one of the victims died as a result.

Both people had received the vaccine less than 14 days before symptoms began. The Danish Medicines Agency also confirmed the “serious reports” on Twitter, but did not provide any details. First the Danish newspaper Ekstra Bladet reported on it. Accordingly, one of the victims should be a 30-year-old woman.

Several European countries had suspended AstraZeneca’s vaccinations after the vaccinees had developed blood clots in very rare cases. According to the Paul Ehrlich Institute (PEI) responsible for vaccines in Germany, the suspected cases in Germany were thromboses in the brain, which rarely occur.

At the same time, those affected had a lack of blood platelets and bleeding had occurred. According to the PEI, it is a serious disease that is difficult to treat. Vaccinations with the drug from AstraZeneca were therefore temporarily suspended in Germany.

Symptoms usually occur 4 to 16 days after vaccination

An investigation by the European Medicines Agency (Ema) could not rule out a connection between the vaccinations and the blood clots. However, the experts continue to recommend the vaccine because the benefits clearly outweigh the risks.

Germany then resumed vaccinations with the agent. Vaccinated persons should now be informed about the possible risks and symptoms. These are warning signs that usually appear 4 to 16 days after vaccination:

On Friday, Greifswald researchers presented a possible explanation for the symptoms. According to this, special antibodies that activate the body’s own blood platelets, so-called thrombocytes, were found in the blood of those affected. Usually this happens with a wound. The platelets ensure that it closes again. In the brain, however, this misdirected activation can lead to blood clots.

Possible cause and therapy found

The scientists at the University Clinic Greifswald around Andreas Greinacher have also developed a test procedure that can prove the cause of the thrombosis.

The Society for Thrombosis and Hemostasis Research has published recommendations for doctors based on the Greifswald findings. She assumes that the formation of clots in people with sinus vein thrombosis and thrombocytopenia can be stopped by giving high doses of intravenous immunoglobulins.

Denmark will decide on AstraZeneca vaccine on Thursday

So far, 13 cases of sinus vein thrombosis shortly after an AstraZeneca vaccination have been reported in Germany, all of which were associated with a lack of blood platelets, a so-called thrombocytopenia. Twelve women under the age of 55 and one man were affected. Two cases were fatal. Around 1.6 million people in Germany were vaccinated with the AstraZeneca substance.

Denmark suspended AstraZeneca vaccinations on March 11 and has not yet resumed. A decision for further use is expected on Thursday.

According to the Danish authorities on Thursday, ten suspected cases of thrombosis that had occurred after vaccination with the AstraZeneca agent were examined. One of these cases was fatal. So far, around 140,000 people in Denmark have been immunized with the vaccine.

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